Comparably, BMP7 activity was also within normal limits in PXE, but BMP2 was considerably overexpressed in the whiskers and Bruch’s membrane of Abcc6 KO mice as well as in the mid-dermis and fibroblasts of PXE patients, co-localizing with the elastic fibre mineralization. Here, BMP2 is linked to pseudoxanthoma elasticum (inherited or acquired).