BRCA2 and ovarian carcinoma: In ovarian cancer OVCA433 cells (Figure 1B), the interruption of Aur A did not alter the expression of Aur B, but the knockdown of Aur B enhanced the expression of Aur A. The silencing of Aur A or/and Aur B promoted the expressions of BRCA1 and BRCA2, compared with in scrambled shRNA-treated control cells.