Treatment of prostate cancer cells with gliotoxin and chetomin blocked the ability of HIF-1α to interact with p300, which is in accordance with previous cellular studies that showed disruption of the HIF-1α/p300 complex in HepG2 liver hepatocellular cells with chetomin [23], as well as in vitro studies that used recombinant proteins to show that gliotoxin [19,22] and chetomin [19,22,23] disrupted the binding of HIF-1α and p300. Here, EP300 is linked to Familial prostate cancer.