On the other hand we observed a significantly decreased percentage of Helios+ cells in CD4+CD25-Foxp3+ T cells in SLE patients (63.3 ± 4%) as compared to CD4+Foxp3+CD25+ from HC (P <0.0001) or SLE patients (P <0.0001). Here, FOXP3 is linked to systemic lupus erythematosus.