Due to tissue specific signaling cascades, disturbing the miR-125b equilibrium can have opposing effects: if miR-125b is downregulated, the “good guy” with its tumor suppressive functions is lost, oncogenic pathways (e.g., ERBB2/3) are activated and pro-apoptotic cascades are repressed, resulting in malignant transformation. Here, ERBB2 is linked to neoplasm.