SIRT3 and neoplasm: Intratumoral Sirt3 also showed prognostic role in other groups when classified by the following variables (Table 3): large tumor (>5 cm) (OS, P = 0.003; TTR, P = 0.046), single tumor (OS, P < 0.001; TTR, P = 0.011), tumor with encapsulation (OS, P = 0.002; TTR, P = 0.036), tumor differentiation grade I-II (OS, P < 0.001; TTR, P = 0.007).