INS and type 1 diabetes mellitus: The EGP was 10 ± 7 μmol·kg−1·min−1 in normal rats and 108 ± 9 μmol·kg−1·min−1 in diabetic rats during the hyperinsulin clamps, which suggested that insulin greatly suppressed the EGP in normal rats, while the effects were limited in the type 1 diabetes rats.