SERPINE1 and type 2 diabetes mellitus: Festa et al. showed higher levels of hs-CRP and PAI-1 in individuals with increased insulin resistance who converted to T2DM in a mean period of 5.2 years versus converters with decreased first-phase insulin secretion, suggesting that insulin resistance rather than impaired β-cell function contributes to the proinflammatory state in prediabetic individuals [15].