Because inflammation is a common feature between atherosclerosis, insulin resistance, and T2DM, and atherothrombosis might exhibit many years before the onset of T2DM, the objective of the present study was to evaluate serum levels of some proinflammatory and prothrombotic markers such as hs-CRP and fibrinogen in subjects with NGT, pre-DM, and T2DM, and to establish their relationship with other traditional cardiovascular risk factors before clinical manifestations of CVD. This evidence concerns the gene CRP and diabetes mellitus.