However, most of the studies evaluating PCT in invasive fungal infections are limited by small case counts; a recent meta-analysis including 8 studies with 474 episodes of suspected infection (155 confirmed or probable invasive fungal infections) showed a pooled sensitivity of 0.82 (95% CI, 0.48–0.95) and specificity of 0.80 (95% CI, 0.60–0.91) [76]. The gene discussed is CALCA; the disease is infection.