TNF and Neonatal sepsis: Sugitharini also looked at a variety of mediators in neonatal sepsis [45] including granule-associated mediators (neutrophils elastase (NE), myeloperoxidase (MPO), and nitric oxide (NO)), proinflammatory cytokines (TNFα, IL-1β, and IL-6), anti-inflammatory cytokines (IL-10 and IL-13), chemokines (IL-8 and monocyte chemotactic protein (MCP-1) and novel cytokines).