APOE and familial hypercholesterolemia: Carriage of the X2 allele of the Apo B gene significantly predisposes an individual to hypercholesterolemia and increased levels of LDLP and the Apo B.The S2 allele of the Apo C111 gene and the E2 allele of the Apo E gene are also genetic markers of hypertriglyceridemia.