It should be noted that the death of motor neurons in ALS may be not anautonomous cell process, since the expression of SOD1 mutantsselectively in motor neurons does not lead to neurodegeneration in transgenicmice [13], while a toxic effect has beenshown for astrocytes [14] and microglialcells [3]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.