Kimoto and coworkers have assessed its antitumour activity on different phenotypes of human leukaemia cell lines such as lymphocytic leukaemia (both cell lines of T-cell and B-cell), myeloid and monocytic leukaemia, and nonlymphoid nonmyeloid leukaemia cell lines and found that it induced apoptotic cell death (marked by appearance of apoptotic bodies and DNA fragmentation) in all the tested cells; and they suggested that this effect may be partly associated with upregulation of Fas expression and loss of mitochondrial membrane potential [138]. This evidence concerns the gene FAS and leukemia.