A renewed interest in prostatic acid phosphatase (i.e., a nonspecific phosphomonoesterase synthesized in prostate epithelial cells, whose level proportionally increases with prostate cancer progression) has been shown, because of its usefulness in prognosticating intermediate to high-risk prostate cancers and its success in the immunotherapy of prostate cancer [122]. This evidence concerns the gene ACP3 and Familial prostate cancer.