Based on these data and according to the OECD guidelines [5], the main possible MoAs starting from xenobiotic interaction with PPARγ as a MIE, passing through downstream transcriptional dysregulation, and resulting in the first two stages of NAFLD, namely, liver steatosis and nonalcoholic steatohepatitis (NASH), are outlined. The gene discussed is PPARG; the disease is metabolic dysfunction-associated steatohepatitis.