DAB2 and ovarian carcinoma: The gene Disabled-2 (Dab2) which also names DOC-2 (Differentially expressed in the Ovarian Carcinoma 2, DOC-2) owns two different splicing formats, and encodes two isoforms (p96-Dab2 and p67-Dab2).1,2 The main functional domain is the phosphotyrosine binding domain (PTB) of the N-terminal, which is a highly conserved sequence and plays a variety of functional roles in endocytosis, cell mitosis, and growth factor signaling.3,4 Especially, the p96-Dab2 is essential for the development of visceral endoderm during mouse embryogenesis and homologous with 93% full-length of mouse Dab2.