Results showed that ratio of Dab2 promoter hypermethylation is 34.54% in cancer tissues which Dab2 expression are lost, and Dab2 promoter hypermethylation might play a key role in the down-regulated expression of Dab2 in human cancer tissues (OR = 24.45, 95% CI: 11.00 - 54.32, P < 0.001; I2 = 45%, P heterogeneity = 0.14) (Fig.3). This evidence concerns the gene DAB2 and cancer.