The anti-tTG antibodies are highly sensitive and specific for the diagnosis of CD.12 Enzyme-linked immune sorbent assay (ELISA) tests for IgA anti-tTG antibodies are now widely available and are easier to perform, less observer-dependent, and less costly than the immunofluorescence assay used to detect IgA EMA antibodies.13 The gene discussed is CD79A; the disease is Cowden disease.