Chinese cervical cancer patients account for 1/3 of the patients worldwide, the number of which is now rapidly rising.2 Squamous cell carcinoma antigen (SCCA), as the serine protease inhibitor (Serpin) family of proteins, can be used as a biomarker for aggressive squamous cell carcinoma in cancers of cervix, lung and liver in case of elevated expression. Here, SERPINB3 is linked to cancer.