In soft tissues and visceral organs TSP1 inhibits blood flow following ischemia reperfusion injury (IRI) (Isenberg et al., 2008b; Csanyi et al., 2012) while TSP1−/− (Isenberg et al., 2007a, 2008c) and CD47−/− animals (Rogers et al., 2012) display enhanced blood flow following ischemia and IRI. The gene discussed is THBS1; the disease is ischemia.