This subsequently reduces the level of pro-inflammatory factors, such as the cytokines TNF-α and IL-1β (Eyre and Baune, 2012), chemokines (Ostrowski et al., 2001), TLRs (Gleeson et al., 2006), and CRP (Koletzko, 2003), helping in alleviating both systemic and neuroinflammation, the latter being the causal factor for most psychiatric disorders. This evidence concerns the gene IL1B and psychiatric disorder.