Though microglia are neuroprotective, their overexpression or sustained stimulation can result in enhanced production of cytokines (e.g., IL-1β and TNF-α; Sawada et al., 1989; Hanisch, 2002), as well as in the expression of class I and II major histocompatibility complex antigens as seen in a RCT in rodents and in the post-mortem brain tissues of AD and age-matched control cases (Tooyama et al., 1990), respectively. This evidence concerns the gene IL1B and Alzheimer disease.