After adjustment for potential confounding factors, such as age, BMI, smoking habits, and diabetes, multivariable linear regression analysis showed that only CHA2DS2-VASc score (R2 0.431, B −0.227, P < 0.001) and sCD40L (R2 0.392, B  −0.524, P < 0.001) were independently correlated to adiponectin. This evidence concerns the gene CD40LG and diabetes mellitus.