Regarding cellular responses, CXCR7 stimulation enhances cell survival of tumor cells, e.g., by reduction of temozolomide-induced apoptosis in glioblastoma cells or of cell adhesion (Burns et al. 2006; Miao et al. 2007; Hattermann et al. 2010, 2012). This evidence concerns the gene ACKR3 and glioblastoma.