Silencing MUC1-C in triple-negative (ER-/PR-/HER2-) MDA-MB-468 cells (Fig. 3C) also resulted in substantial suppression of mammosphere size (Fig. 3D, left) and SFE (Fig. 3D, right), indicating that these effects of silencing MUC1-C are independent of breast cancer cell subtype. The gene discussed is ERBB2; the disease is breast carcinoma.