In PCa cells EGF induced the disruption of epithelial cell plasticity, upregulated snail, enhanced motility and invasion mainly through Akt-dependent mechanisms, eventually promoting EMT and invasiveness [38].Fisetin reduces EGF induced YB-1 phosphorylation and reverses EMT, suggesting fisetin's EMT inhibiting potential. This evidence concerns the gene EGF and posterior cortical atrophy.