HCRT and Hypoglycemia: In contrast, hypoglycemia has been shown to robustly increase orexinergic neuron activation (Sakurai et al. 1998; Moriguchi et al. 1999; Cai et al. 2001) and orexin levels (Moriguchi et al. 1999; Cai et al. 1999, 2001; Griffond et al. 1999), specifically, orexin A (Liu et al. 2001).