By extension, it is therefore possible that the local concentration of SB-649868 at CNS OxR1 and OxR2 receptors was insufficient to have any pharmacological effect even if central orexin signaling had been adequately stimulated by hypoglycemia; in other words, the compound had poor antagonist efficacy at the bioavailable dose. The gene discussed is HCRT; the disease is Hypoglycemia.