In experimental studies, the TNF-alpha system – whose activity can be assessed by the plasma level of sTNF-R1 [8]– was found to influence calcium [9], [10] and potassium [11], [12] channels affecting QT time (shortening for the former and prolongation for the latter) and the susceptibility to arrhythmia [13]. This evidence concerns the gene TNF and cardiac arrhythmia.