RAC2 and melanoma: The right hemithorax (injected with WT BMDMs) showed luciferase activity and B16 metastatic nodules while there was no B16 melanoma or luciferase signal and minimal metastatic nodules detected within the left hemithorax (injected with WT GBMDM vs. Rac2-/- BMDM) (Figure 6E).