NUMB and hepatocellular carcinoma: For overall survival analysis, 107 HCC patients with sufficient and valid follow-up data were included, As shown in Figure 3A, patients with low Numb expression had longer overall survival time, whereas those with high Numb expression had shorter overall survival time (Figure 3A, log-rank, P = 0.001); the median OS times in the High Numb group (n = 43) and Low Numb group (n 64) of HCC patients were 23.3 months (95% CI, 16.6 months-30.0months) and 31.9 months (95% CI, 26.3 months-37.6 months), respectively.