Even, if the data using adenovirus P2Y13R- shRNA infection in apoE−/− mice, clearly emphasize the exclusive role of liver P2Y13R in the atherosclerosis inhibition we have observed, we cannot totally exclude the putative role of the P2Y13 agonist on brain and/or spleen P2Y13R in specific atherosclerotic disease such as re-infarction following a primary myocardial infarction as described recently. This evidence concerns the gene APOE and myocardial infarction.