BRAF and cardiofaciocutaneous syndrome: The child described by Nystrom et al. [21], who had a clinical diagnosis of NS because of pulmonic stenosis and NS facial dysmorphisms, was discovered to carry the BRAF mutation p.(Lys499Glu). The authors proposed a gene-based classification of RASopathies and suggested that NS and CFC are allelic disorders of BRAF. A BRAF analysis was performed for our proband, and no mutation was found.