The rate of HPA expression was found to be closely related to tumor size (>3.1; P = 0.036), tumor stage (T3 -T4; P = 0.000), lymphatic metastasis (N1-3; P = 0.012), distant metastasis (M1; P = 0.000), pathologic stage (III-IV; P = 0.000) and histological grade (G3-G4; P = 0.016). This evidence concerns the gene HPSE and neoplasm.