In comparison to the patients with established RA in the Dartmouth RA Cohort, the recent-onset RA patients showed a stronger relationship between CXCL13 and IgG ACPA with P = 0.006 (r = 0.21) (Figure 3D) and P = 0.02 by tertile analysis (data not shown), respectively, but no relationship between serum IgG and CXCL13 level was observed (r = 0.11, P = 0.14) (data not shown). This evidence concerns the gene CXCL13 and rheumatoid arthritis.