Similarly, no relationship was seen (n = 111 patients with C4 (please italicize) gene copy number determination) with C4B gene copy number deficiency (P = 0.69), C4A deficiency (P = 0.56), or total C4 deficiency, defined as C4 gene copy number <4 (P = 0.35) (data not shown). This evidence concerns the gene C4A and hyperinsulinemic hypoglycemia, familial, 4.