The observation that local thorax irradiation also affects the T cell compartment in peripheral lymphoid organs supports earlier findings about systemic effects of a local irradiation: In this regard, irradiation of prostate tumors grown on the hint-leg of C57BL/6 mice resulted in the accumulation of CD4+ CD25hi FoxP3+ lymphocytes in peripheral lymphoid organs [30]. The gene discussed is FOXP3; the disease is prostate neoplasm.