Because angiogenesis plays a critical role in tumor survival, growth, and metastasis, inhibition of the key angiogenesis pathway mediated via vascular endothelial growth factor (VEGF)/VEGF receptor signaling, either at the ligand level (e.g. bevacizumab) or at the receptor level (e.g. the tyrosine kinase inhibitors [TKIs] sorafenib, sunitinib, pazopanib, or axitinib, among many others), has been intensively evaluated in advanced NSCLC [4,5]. Here, VEGFA is linked to neoplasm.