TFAP2A and TFAP2C have been shown to participate in tumorigenesis by controlling the expression of many cancer-related genes, such as vascular endothelial growth factor (VEGF), P21, Rb, TP53, ERa, BCL2, cKIT, MMP-2, E-cadherin, and c-myc[20-24]. This evidence concerns the gene TFAP2C and cancer.