TFAP2B and lung carcinoma: To evaluate our hypothesis that TFAP2B plays a potential oncogenic role in lung cancer, we performed in vitro studies to investigate the underlying molecular mechanisms and found that TFAP2B knockdown inhibited cell viability, clonogenicity, and angiogenesis and induced apoptosis in vitro but that TFAP2B overexpression had the opposite effect in H1299 lung cancer cells.