Notably, emerging evidence has established the following: i) IGF1R is a potential link between genetic and environmental interactions (3,6); ii) convergence exists between IGF1R-related cell proliferation pathways and BRCA1-related tumor protective pathways (3); and iii) BRCA1 mutation-related cancer may be regulated by the IGF1R signaling pathway (3). The gene discussed is BRCA1; the disease is neoplasm.