ELISA results showed that the ovarian cancer cells, CAOV3 and SKOV3, were stimulated by different LPA concentrations (0, 5 and 20 μM) for 24 h, and that the expression of CXCL12 protein in the supernatant significantly increased in a dose-dependent manner, with a significant difference among each group (F=34.871, P=34.871; and F=14.218, P=14.218, respectively). This evidence concerns the gene CXCL12 and ovarian carcinoma.