CXCR4 and ovarian carcinoma: The present study assessed the effect of the CXCL12-CXCR4 axis regulated by LPA on ovarian cancer cell proliferation, migration and invasion, and demonstrated that PTX inhibited the regulation of CXCL12 by LPA, and decreased the proliferation, migration and invasion ability of ovarian cancer cells that were enhanced by CXCL12 and LPA.