TP53 and dysplasia: Previously, Yao et al proposed four characteristics of the malignantly transformed lesions associated with gastric hyperplasia polyps: i) lesions are predominantly of the well-differentiated type, although, a small number of lesions of the poorly differentiated type have also been reported; ii) malignant transformation has been suggested to be associated with dysplasia, although, involvement of intestinal metaplasia remains unknown; iii) the mucin phenotype appears to be of the gastric type in a number of cases; and iv) p53 may be important in the malignant transformation (14).