Zhang et al reported that the PI3K/Akt pathway is expressed in 71.7 (43/60) and 68.3% (41/60) of colon cancer and is closely associated with serous coat infiltration and lymphatic metastasis (21), serving as an independent prognostic marker for patients with colorectal cancer (CRC) (22). This evidence concerns the gene AKT1 and colorectal cancer.