Besides its expression in fibroblasts, smooth muscle and endothelial cells, MMP-14 is also found in the majority of tumor types, including skin, lung, stomach, colon, liver, kidney, breast, bladder and brain, and is one of the most closely linked enzymes, of the MMP family, to the molecular mechanisms of tumor invasion and metastasis (16,17). Here, MMP14 is linked to neoplasm.