The present study summarized that different members of the CRMP family are involved in different tumors; CRMP1 and CRMP2 in lung cancer, CRMP2 in breast and colorectal cancer, CRMP4 in prostate cancer, pancreatic cancer and neuroblastoma, and CRMP5 in neuroendocrine lung cancer and glioblastoma. This evidence concerns the gene DPYSL3 and familial pancreatic carcinoma.