Although the exact mechanisms of HD pathogenesis remain unknown and cannot be discussed here in detail, they involve the formation of protein aggregates by polyQ expanded Htt, as well as the interaction of mutant Htt with numerous proteins that are involved in energy metabolism, protein and vesicle transport, and regulation of gene transcription (Li and Li, 2004; Jones and Hughes, 2011). This evidence concerns the gene HTT and Huntington disease.