Area under curve (AUC) of glucose exposure >150 mg/dl (8.3mmol/l) vs. time for the first 24 hours of the insulin infusion (control 28.4 vs. protocol 14.8; P < 0.001), median time to blood glucose <150 mg/dl (8.3mmol/l) (control 9.4 h vs. protocol 2.1h; P < 0.001), and percentage blood glucose <65 mg/dl (3.6 mmol/l) as a marker for hypoglycaemia (control 9.8% vs. protocol 16.7%; NS). This evidence concerns the gene INS and Hypoglycemia.