Furthermore, it has been recently shown that the overexpression of the LMO2 oncogene in the thymus induce the emergence of a pre-leukemic stem cell (pre-LSC) population [20] but the identification of the cell of origin of T-ALL and the mechanisms by which these oncogenes reprogram normal thymocytes to become T-LIC remain unclear. This evidence concerns the gene LMO2 and acute lymphoblastic leukemia.