To establish a causal connection between apoptotic events and depression and/or anxiety-like behaviors in comorbid mice, we performed correlation analyses between the apoptotic parameters of TUNEL staining, caspase-3 levels and Bcl-2 levels in the hippocampus and frontal cortex and behavioral test parameters generated from OFT, TST and FST using the Spearman’s rank test. This evidence concerns the gene CASP3 and depressive disorder.