AKT1 and cardiac hypertrophy: We further found that Nek6 was implicated in the regulation of the Akt/GSK-3β signaling during the progress of cardiac hypertrophy both in vivo and in vitro. Previously studies have demonstrated that a number of signaling pathways including the MAPK, Akt/GSK-3β and calcineurin/nuclear factor of activated T cells (NFAT) signaling cascades play roles in cardiac hypertrophy [14], [15], [17].