To address this, we knocked down BRMS1 in four NSCLC cell lines with different p53 and K-Ras status (H1975: p53 WT/K-Ras WT; H1299: p53 null/K-Ras WT; A549: p53 WT/K-RasS12, H358: p53 null/K-RasC12) and a non-migrating NSCLC cells, Calu-3 (p53 mut/K-Ras WT) (Fig. S3) (p53 status: http://p53.free.fr/Database/Cancer_cell_lines/NSCLC.html) [24]. The gene discussed is KRAS; the disease is non-small cell lung carcinoma.