MAPK3 and Insulin resistance: A close relationship between chronic inflammation and insulin resistance has been well established, and the IKKβ pathway is a target for insulin resistance [31]; in addition, IκB was activated by 20-HETE (data not shown), which is consistent with pervious observations that 20-HETE stimulates NFκB activation and promotes proinflammatory cytokine production via an ERK1/2-dependent pathway [17].