We first screened the reported deubiquitinases for TRAF3 and found that HSCARG interacted with OTUB1 more potently than OTUB2, UCHL1, OTUD7B, and USP25 (Figure 3A, Figure S3B), and this interaction was enhanced by viral infection (Figure 3A). The gene discussed is OTUB2; the disease is viral infectious disease.