ITIH4 and AIDS: As the dual tropic V3 loop which was used in this study to derive the present complete HIV-1 gp120 V3 loop : CCR5 complex structure is identical to the V3 loop used also to derive HIV-1 gp120 V3 loop : CXR4 complex structure [30], a comparison between the V3 loop bound conformations and the interaction free energies for every V3 loop residue in complex with CCR5/CXCR4 is of utmost importance for paving the way toward the design of a new generation of potential anti-AIDS therapeutics which can target both coreceptors.