The use of whole-genome and whole-exome sequencing in hereditary cancer genetics has already shown promising results in the research setting and has allowed for the identification of PALB2 and ATM as pancreatic cancer susceptibility genes.30,31 Whole-exome sequencing also led to the identification of MAX as a hereditary pheochromocytoma susceptibility gene, and POLD1 and POLE as susceptibility genes in hereditary colorectal cancer.32,33. Here, POLE is linked to familial colorectal cancer.